Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells
Details
Publication Year 2021-07-20, Volume 36, Issue #3, Page 109430
Journal Title
Cell Reports
Abstract
While the intrinsic apoptosis pathway is thought to play a central role in shaping the B cell lineage, its precise role in mature B cell homeostasis remains elusive. Using mice in which mature B cells are unable to undergo apoptotic cell death, we show that apoptosis constrains follicular B (FoB) cell lifespan but plays no role in marginal zone B (MZB) cell homeostasis. In these mice, FoB cells accumulate abnormally. This intensifies intercellular competition for BAFF, resulting in a contraction of the MZB cell compartment, and reducing the growth, trafficking, and fitness of FoB cells. Diminished BAFF signaling dampens the non-canonical NF-κB pathway, undermining FoB cell growth despite the concurrent triggering of a protective p53 response. Thus, MZB and FoB cells exhibit a differential requirement for the intrinsic apoptosis pathway. Homeostatic apoptosis constrains the size of the FoB cell compartment, thereby preventing competition-induced FoB cell atrophy.
Publisher
Elsevier
Keywords
Baff; Nf-κb; cell growth; cellular lifespan; follicular B cells; intercellular competition; intrinsic apoptosis; marginal zone B cells; mature B cell homeostasis; p53
WEHI Research Division(s)
Epigenetics And Development; Blood Cells And Blood Cancer
PubMed ID
34289356
Open Access at Publisher's Site
https://doi.org/10.1016/j.celrep.2021.109430
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-08-16 10:40:35
Last Modified: 2021-08-16 10:49:37
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