Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome

Roth-Schulze, AJ; Penno, MAS; Ngui, KM; Oakey, H; Bandala-Sanchez, E; Smith, AD; Allnutt, TR; Thomson, RL; Vuillermin, PJ; Craig, ME; Rawlinson, WD; Davis, EA; Harris, M; Soldatos, G; Colman, PG; Wentworth, JM; Haynes, A; Barry, SC; Sinnott, RO; Morahan, G; Bediaga, NG; Smyth, GK; Papenfuss, AT; Couper, JJ; Harrison, LC

Author(s): Roth-Schulze, AJ; Penno, MAS; Ngui, KM; Oakey, H; Bandala-Sanchez, E; Smith, AD; Allnutt, TR; Thomson, RL; Vuillermin, PJ; Craig, ME; Rawlinson, WD; Davis, EA; Harris, M; Soldatos, G; Colman, PG; Wentworth, JM; Haynes, A; Barry, SC; Sinnott, RO; Morahan, G; Bediaga, NG; Smyth, GK; Papenfuss, AT; Couper, JJ; Harrison, LC;
Details: Publication Year 2021-08-06,Volume 9,Issue #1,Page 167
Journal Title: Microbiome
Abstract: BACKGROUND: The gut microbiome changes in response to a range of environmental conditions, life events and disease states. Pregnancy is a natural life event that involves major physiological adaptation yet studies of the microbiome in pregnancy are limited and their findings inconsistent. Pregnancy with type 1 diabetes (T1D) is associated with increased maternal and fetal risks but the gut microbiome in this context has not been characterized. By whole metagenome sequencing (WMS), we defined the taxonomic composition and function of the gut bacterial microbiome across 70 pregnancies, 36 in women with T1D. RESULTS: Women with and without T1D exhibited compositional and functional changes in the gut microbiome across pregnancy. Profiles in women with T1D were distinct, with an increase in bacteria that produce lipopolysaccharides and a decrease in those that produce short-chain fatty acids, especially in the third trimester. In addition, women with T1D had elevated concentrations of fecal calprotectin, a marker of intestinal inflammation, and serum intestinal fatty acid-binding protein (I-FABP), a marker of intestinal epithelial damage. CONCLUSIONS: Women with T1D exhibit a shift towards a more pro-inflammatory gut microbiome during pregnancy, associated with evidence of intestinal inflammation. These changes could contribute to the increased risk of pregnancy complications in women with T1D and are potentially modifiable by dietary means. Video abstract.
Publisher: BMC
Keywords: Gut; Inflammation markers; Metagenomics; Microbiome; Pregnancy; Quantitative PCR; Type 1 diabetes
Research Division(s): Bioinformatics; Population Health And Immunity
PubMed ID: 34362459
Publisher's Version: https://doi.org/10.1186/s40168-021-01104-y
Open Access at Publisher's Site: https://doi.org/10.1186/s40168-021-01104-y
Terms of Use/Rights Notice: Refer to copyright notice on published article.
Documents: Roth Schulze et al_Microbiome.pdf - (1.23MB, application/pdf)

Creation Date: 2021-09-17 09:12:05

Last Modified: 2021-09-17 09:28:24