An online, person-centered, risk factor management program to prevent cognitive decline: Protocol for a prospective behavior-modification blinded endpoint randomized controlled trial
- Author(s)
- Lim, YY; Ayton, D; Perin, S; Lavale, A; Yassi, N; Buckley, R; Barton, C; Bruns, L; Morello, R; Pirotta, S; Rosenich, E; Rajaratnam, SW; Sinnott, R; Brodtmann, A; Bush, AI; Maruff, P; Churilov, L; Barker, A; Paseon, MP;
- Journal Title
- Journal of Alzheimer's Disease
- Abstract
- BACKGROUND: Several modifiable risk factors for dementia have been identified, although the extent to which their modification leads to improved cognitive outcomes remains unclear. OBJECTIVE: The primary aim is to test the hypothesis that a behavior modification intervention program targeting personalized risk factors prevents cognitive decline in community-dwelling, middle-aged adults with a family history of dementia. METHODS: This is a prospective, risk factor management, blinded endpoint, randomized, controlled trial, where 1510 cognitively normal, community-dwelling adults aged 40-70 years old will be recruited. Participants will be screened for risk factors related to vascular health (including physical inactivity), mental health, sleep, and cognitive/social engagement. The intervention is an online person-centered risk factor management program: BetterBrains. Participants randomized to intervention will receive telehealth-based person-centered goal setting, motivational interviewing, and follow-up support, health care provider communication and community linkage for management of known modifiable risk factors of dementia. Psychoeducational health information will be provided to both control and intervention groups. RESULTS: The primary outcome is favorable cognitive performance at 24-months post-baseline, defined as the absence of decline on one or more of the following cognitive tests: (a) Cogstate Detection, (b) Cogstate One Card Learning, (c) Cogstate One Back, and (d) Cognitive Function Instrument total score. CONCLUSION: We will test the hypothesis that the BetterBrains intervention program can prevent cognitive decline. By leveraging existing community services and using a risk factor management pathway that tailors the intervention to each participant, we maximize likelihood for engagement, long-term adherence, and for preserving cognitive function in at-risk individuals.
- Publisher
- IOS Press
- Keywords
- Alzheimer’s disease; clinical trial; cognitive decline; dementia; lifestyle intervention; non-pharmacological; randomized control trial
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 34420970
- Publisher's Version
- https://doi.org/10.3233/jad-210589
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-09-17 11:04:10
Last Modified: 2021-09-17 11:12:30