Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives
- Author(s)
- Jacquelot, N; Seillet, C; Souza-Fonseca-Guimaraes, F; Sacher, AG; Belz, GT; Ohashi, PS;
- Details
- Publication Year 2021-08-22,Volume 22,Issue #16,Page 9044
- Journal Title
- International Journal of Molecular Sciences
- Abstract
- Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) are specific innate lymphoid cell subsets that are key for the detection and elimination of pathogens and cancer cells. In liver, while they share a number of characteristics, they differ in many features. These include their developmental pathways, tissue distribution, phenotype and functions. NK cells and ILC1 contribute to organ homeostasis through the production of key cytokines and chemokines and the elimination of potential harmful bacteria and viruses. In addition, they are equipped with a wide range of receptors, allowing them to detect "stressed cells' such as cancer cells. Our understanding of the role of innate lymphoid cells in hepatocellular carcinoma (HCC) is growing owing to the development of mouse models, the progress in immunotherapeutic treatment and the recent use of scRNA sequencing analyses. In this review, we summarize the current understanding of NK cells and ILC1 in hepatocellular carcinoma and discuss future strategies to take advantage of these innate immune cells in anti-tumor immunity. Immunotherapies hold great promise in HCC, and a better understanding of the role and function of NK cells and ILC1 in liver cancer could pave the way for new NK cell and/or ILC1-targeted treatment.
- Publisher
- MDPI
- Keywords
- Ilc1; cancer; hepatocellular carcinoma; immunotherapies; innate lymphoid cells; liver; natural killer cells
- Research Division(s)
- Immunology
- PubMed ID
- 34445750
- Publisher's Version
- https://doi.org/10.3390/ijms22169044
- Open Access at Publisher's Site
https://doi.org/10.3390/ijms22169044- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-09-17 11:23:12
Last Modified: 2021-09-17 11:41:33