Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus
Details
Publication Year 2021-08-26,Volume 12,Issue #1,Page 5125
Journal Title
Nature Communications
Abstract
Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children globally, but little is known about within-host RSV diversity. Here, we characterised within-host RSV populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017-2020. RSV-B had lower consensus diversity than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which has been associated with reduced susceptibility to nirsevimab (MEDI8897), a novel RSV monoclonal antibody under development. In addition, several minor variants were identified in the antigenic sites of the F protein, one of which may confer resistance to palivizumab, the only licensed RSV monoclonal antibody. The differences in within-host virus populations emphasise the importance of monitoring for vaccine efficacy and may help to explain the different prevalences of monoclonal antibody-escape mutants between the two subgroups.
Publisher
NPG
Research Division(s)
Advanced Technology And Biology
PubMed ID
34446722
Open Access at Publisher's Site
https://doi.org/10.1038/s41467-021-25265-4
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-09-17 11:23:18
Last Modified: 2022-02-23 02:25:49
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