Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus
- Author(s)
- Lin, GL; Drysdale, SB; Snape, MD; O'Connor, D; Brown, A; MacIntyre-Cockett, G; Mellado-Gomez, E; de Cesare, M; Bonsall, D; Ansari, MA; Oner, D; Aerssens, J; Butler, C; Bont, L; Openshaw, P; Martinon-Torres, F; Nair, H; Bowden, R; Resceu Investigators,; Golubchik, T; Pollard, AJ;
- Details
- Publication Year 2021-08-26,Volume 12,Issue #1,Page 5125
- Journal Title
- Nature Communications
- Abstract
- Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children globally, but little is known about within-host RSV diversity. Here, we characterised within-host RSV populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017-2020. RSV-B had lower consensus diversity than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which has been associated with reduced susceptibility to nirsevimab (MEDI8897), a novel RSV monoclonal antibody under development. In addition, several minor variants were identified in the antigenic sites of the F protein, one of which may confer resistance to palivizumab, the only licensed RSV monoclonal antibody. The differences in within-host virus populations emphasise the importance of monitoring for vaccine efficacy and may help to explain the different prevalences of monoclonal antibody-escape mutants between the two subgroups.
- Publisher
- NPG
- Research Division(s)
- Advanced Technology And Biology
- PubMed ID
- 34446722
- Publisher's Version
- https://doi.org/10.1038/s41467-021-25265-4
- Open Access at Publisher's Site
https://doi.org/10.1038/s41467-021-25265-4- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-09-17 11:23:18
Last Modified: 2022-02-23 02:25:49