Depletion of a Toxoplasma porin leads to defects in mitochondrial morphology and contacts with the ER
- Mallo, N; Ovciarikova, J; Martins-Duarte, ES; Baehr, SC; Biddau, M; Wilde, ML; Uboldi, AD; Lemgruber, L; Tonkin, CJ; Wideman, JG; Harding, CR; Sheiner, L;
- Journal Title
- Journal of Cell Science
- Publication Type
- epub ahead of print
- The Voltage Dependent Anion channel (VDAC) is a ubiquitous channel in the outer membrane of the mitochondrion with multiple roles in protein, metabolite and small molecule transport. In mammalian cells, VDAC, as part of a larger complex including the inositol triphosphate receptor, has been shown to have a role in mediating contacts between the mitochondria and endoplasmic reticulum (ER). We identify VDAC of the pathogenic apicomplexan Toxoplasma gondii and demonstrate its importance for parasite growth. We show that VDAC is involved in protein import and metabolite transfer to mitochondria. Further, depletion of VDAC resulted in significant morphological changes of the mitochondrion and ER, suggesting a role in mediating contacts between these organelles in T. gondii.
- WEHI Research Division(s)
- Infectious Diseases And Immune Defence
- PubMed ID
- Publisher's Version
- Open Access at Publisher's Site
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-09-17 11:23:21Last Modified: 2021-09-17 11:56:03