Depletion of a Toxoplasma porin leads to defects in mitochondrial morphology and contacts with the ER
- Author(s)
- Mallo, N; Ovciarikova, J; Martins-Duarte, ES; Baehr, SC; Biddau, M; Wilde, ML; Uboldi, AD; Lemgruber, L; Tonkin, CJ; Wideman, JG; Harding, CR; Sheiner, L;
- Details
- Publication Year 2021-09-15,Volume 134,Issue #20,Page jcs255299
- Journal Title
- Journal of Cell Science
- Abstract
- The Voltage Dependent Anion channel (VDAC) is a ubiquitous channel in the outer membrane of the mitochondrion with multiple roles in protein, metabolite and small molecule transport. In mammalian cells, VDAC, as part of a larger complex including the inositol triphosphate receptor, has been shown to have a role in mediating contacts between the mitochondria and endoplasmic reticulum (ER). We identify VDAC of the pathogenic apicomplexan Toxoplasma gondii and demonstrate its importance for parasite growth. We show that VDAC is involved in protein import and metabolite transfer to mitochondria. Further, depletion of VDAC resulted in significant morphological changes of the mitochondrion and ER, suggesting a role in mediating contacts between these organelles in T. gondii.
- Publisher
- Company of BIologists
- Research Division(s)
- Infectious Diseases And Immune Defence
- PubMed ID
- 34523684
- Publisher's Version
- https://doi.org/10.1242/jcs.255299
- Open Access at Publisher's Site
https://doi.org/10.1242/jcs.255299- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-09-17 11:23:21
Last Modified: 2021-11-10 10:57:40