Improving outcomes in germ cell cancers using miRNA
- Author(s)
- Conduit, C; Tran, B;
- Journal Title
- Therapeutic Advances in Medical Oncology
- Abstract
- Owing to advances in treatment paradigms across the last five decades, testicular cancer is now eminently curable. However, current serum tumour and imaging biomarkers lack adequate sensitivity, specificity, and predictive value. Subsequently, their utility in detecting active malignancy and informing treatment decisions is minimal in a large proportion of men with testicular cancer. Micro-ribonucleic acids (miRNA), pertinently miR-371a-3p, offer a new tool, which based on early data, appears to fill many of the gaps that existing biomarkers leave. This paper reviews the evolution of the technology, potential limitations, and discusses the clinical relevance of miRNA as it moves towards the clinic.
- Publisher
- SAGE
- Keywords
- blood-based biomarker; germ cell tumour; molecular oncology; predictive biomarker; prognostic biomarker
- Research Division(s)
- Personalised Oncology
- PubMed ID
- 34262617/
- Publisher's Version
- https://doi.org/10.1177/17588359211027826
- Open Access at Publisher's Site
https://doi.org/10.1177/17588359211027826- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-10-26 10:03:41
Last Modified: 2023-06-14 10:27:19