Emerging roles for IL-11 in inflammatory diseases
- Author(s)
- Fung, KY; Louis, C; Metcalfe, RD; Kosasih, CC; Wicks, IP; Griffin, MDW; Putoczki, TL;
- Journal Title
- Cytokine
- Abstract
- Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also associated with several non-malignant inflammatory diseases where its function remains less well-characterized. Here, we summarize current literature surrounding the contribution of IL-11 to the pathogenesis of autoimmune inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, diabetes and systemic sclerosis, as well as other chronic inflammatory conditions such as periodontitis, asthma, chronic obstructive pulmonary disease, psoriasis and colitis.
- Publisher
- Cell Press
- Research Division(s)
- Personalised Oncology; Inflammation
- PubMed ID
- 34689057
- Publisher's Version
- https://doi.org/10.1016/j.cyto.2021.155750
- Open Access at Publisher's Site
https://doi.org/10.1016/j.cyto.2021.155750- NHMRC Grants
- NHMRC/34689057, NHMRC/1147621, NHMRC/1098643,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-11-09 10:48:06
Last Modified: 2021-12-07 09:48:33