Serology for Plasmodium vivax surveillance: a novel approach to accelerate towards elimination
Journal Title
Parasitology International
Publication Type
epub ahead of print
Abstract
Plasmodium vivax is the most widespread causative agent of human malaria in the world. Despite the ongoing implementation of malaria control programs, the rate of case reduction has declined over the last 5 years. Hence, surveillance of malaria transmission should be in place to identify and monitor areas that require intensified malaria control interventions. Serological tools may offer additional insights into transmission intensity over parasite and entomological measures, especially as transmission levels decline. Antibodies can be detected in the host system for months to even years after parasite infections have been cleared from the blood, enabling malaria exposure history to be captured. Because the Plasmodium parasite expresses more than 5000 proteins, it is important to a) understand antibody longevity following infection and b) measure antibodies to more than one antigen in order to accurately inform on the exposure and/or immune status of populations. This review summarises current practices for surveillance of P. vivax malaria, the current state of research into serological exposure markers and their potential role for accelerating malaria elimination, and discusses further studies that need to be undertaken to see such technology implemented in malaria-endemic areas.
Publisher
Elsevier
Keywords
Malaria; Malaria elimination; Multiplex assay; Naturally acquired immunity; Plasmodium vivax; Surveillance
WEHI Research Division(s)
Population Health And Immunity
Open Access at Publisher's Site
https://doi.org/10.1016/j.parint.2021.102492
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-11-09 10:48:12
Last Modified: 2021-11-09 11:04:53
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