The role of LNK (SH2B3) in the regulation of JAK-STAT signalling in haematopoiesis
Details
Publication Year 2022-12-24,Volume 15,Issue #1,Page 24
Journal Title
Pharmaceuticals
Abstract
LNK is a member of the SH2B family of adaptor proteins and is a non-redundant regulator of cytokine signalling. Cytokines are secreted intercellular messengers that bind to specific receptors on the surface of target cells to activate the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling pathway. Activation of the JAK-STAT pathway leads to proliferative and often inflammatory effects, and so the amplitude and duration of signalling are tightly controlled. LNK binds phosphotyrosine residues to signalling proteins downstream of cytokines and constrains JAK-STAT signalling. Mutations in LNK have been identified in a range of haematological and inflammatory diseases due to increased signalling following the loss of LNK function. Here, we review the regulation of JAK-STAT signalling via the adaptor protein LNK and discuss the role of LNK in haematological diseases.
Publisher
MDPI
Keywords
Jak-stat; Sh2b3; myeloproliferative neoplasms
WEHI Research Division(s)
Structural Biology
PubMed ID
35056081
Open Access at Publisher's Site
https://doi.org/10.3390/ph15010024
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2022-02-07 10:12:21
Last Modified: 2022-02-08 11:42:15
An error has occurred. This application may no longer respond until reloaded. Reload 🗙