Genetics of reticular pseudodrusen in age-related macular degeneration
- Author(s)
- Farashi, S; Ansell, BRE; Wu, Z; Abbott, CJ; Pébay, A; Fletcher, EL; Guymer, RH; Bahlo, M;
- Journal Title
- Trends in Genetics
- Publication Type
- epub ahead of print
- Abstract
- Reticular pseudodrusen (RPD) are subretinal deposits that, when observed with age-related macular degeneration (AMD), form a distinct phenotype, often associated with late-stage disease. To date, RPD genetic risk associations overlap six well-established AMD-risk regions. Determining RPD-specific underlying genetic causes by using adequate imaging methods should improve our understanding of the pathophysiology of RPD.
- Publisher
- Elsevier
- Keywords
- age-related macular degeneration; genetic risk factors; genome-wide association studies; multi-modal imaging; reticular pseudodrusen
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 35093239
- Publisher's Version
- https://doi.org/10.1016/j.tig.2022.01.003
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2022-02-18 11:34:18
Last Modified: 2022-02-18 03:10:04