Association between amyloid-beta deposition and cortical thickness in dementia with Lewy bodies
- Author(s)
- Chin, KS; Gajamange, S; Desmond, PM; Villemagne, VL; Rowe, CC; Churilov, L; Yassi, N; Watson, R;
- Journal Title
- Australian and New Zealand Journal of Psychiatry
- Publication Type
- epub ahead of print
- Abstract
- OBJECTIVE: Amyloid-beta often co-exists in dementia with Lewy bodies, but its clinical relevance in dementia with Lewy bodies remains unclear. This study aimed to investigate the clinical and imaging correlates of amyloid-beta deposition in dementia with Lewy bodies, particularly its relationship with cortical thickness in Alzheimer's disease-prone regions and hippocampal volume. METHODS: Twenty-four participants with probable dementia with Lewy bodies underwent high-resolution magnetic resonance imaging and amyloid-beta positron emission tomography imaging using the radiotracer (18)F-NAV4694. Amyloid-beta deposition was quantified and reported using the Centiloid method. RESULTS: Amyloid-beta positivity, defined as Centiloid > 50, was present in 45.8% of dementia with Lewy bodies participants. There were no statistically significant differences in clinical characteristics between Aβ+ and Aβ- dementia with Lewy bodies. Compared with the Aβ- group, Aβ+ dementia with Lewy bodies exhibited greater global cortical thinning as well as in the Alzheimer's disease-prone region of interest, adjusted for age, sex and years of education. A mean cortical thickness of 5.12 mm across a combined meta-region of interest has a sensitivity of 88.9% and specificity of 90.0% in discriminating Aβ+ from Aβ- dementia with Lewy bodies. Hippocampal volume was not different between groups. CONCLUSION: Early structural changes in cortical thickness, but not hippocampal volume, were observed in dementia with Lewy bodies with significant amyloid-beta burden. This may represent an early Alzheimer's disease-related neurodegenerative process.
- Keywords
- Alzheimer’s disease; Dementia with Lewy bodies; amyloid-beta; cortical thickness
- Research Division(s)
- Population Health And Immunity
- Publisher's Version
- https://doi.org/10.1177/00048674221081773
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2022-03-15 10:36:47
Last Modified: 2022-03-15 11:16:45