CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the sulfurea paramutation in Solanum lycopersicum
- Author(s)
- Martinho, C; Wang, Z; Ghigi, A; Buddle, S; Barbour, F; Yarur, A; Gouil, Q; Müller, S; Stam, M; Liu, C; Baulcombe, DC;
- Details
- Publication Year 2022-03-29,Volume 119,Issue #13,Page e2112240119
- Journal Title
- Proceedings of the National Academy of Sciences of the United States of America
- Abstract
- SignificanceParamutation involves the transfer of a repressive epigenetic mark between silent and active alleles. It is best known from exceptional non-Mendelian inheritance of conspicuous phenotypes in maize but also in other plants and animals. Recent genomic studies, however, indicate that paramutation may be less exceptional. It may be a consequence of wide-cross hybridization and may contribute to quantitative trait variation or unstable phenotypes in crops. Using the sulfurea (sulf) locus in tomato, we demonstrate that a self-reinforcing feedback loop involving DNA- and histone-methyl transferases CHROMOMETHYLTRANSFERASE3 (CMT3) and KRYPTONITE (KYP) is required for paramutation of sulf and that there is a change in chromatin organization. These findings advance the understanding of non-Mendelian inheritance in plants.
- Publisher
- NAS
- Keywords
- epigenetic memory; heredity; paramutation; tomato
- Research Division(s)
- Epigenetics And Development
- PubMed ID
- 35324329
- Publisher's Version
- https://doi.org/10.1073/pnas.2112240119
- Open Access at Publisher's Site
https://doi.org/10.1073/pnas.2112240119- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2022-04-08 10:53:27
Last Modified: 2022-04-08 11:17:29