The web of death: the expanding complexity of necroptotic signaling
- Author(s)
- Horne, CR; Samson, AL; Murphy, JM;
- Journal Title
- Trends in Cell Biology
- Publication Type
- epub ahead of print
- Abstract
- The past decade has seen the emergence of the necroptosis programmed cell death pathway as an important contributor to the pathophysiology of myriad diseases. The receptor interacting protein kinase (RIPK)1 and RIPK3, and the pseudokinase executioner protein, mixed lineage kinase domain-like (MLKL), have grown to prominence as the core pathway components. Depending on cellular context, these proteins also serve as integrators of signals, such as post-translational modifications and protein or metabolite interactions, adding layers of complexity to pathway regulation. Here, we describe the emerging picture of the web of proteins that tune necroptotic signal transduction and how these events have diverged across species, presumably owing to selective pressures of pathogens upon the RIPK3-MLKL protein pair.
- Publisher
- Elsevier
- Keywords
- lytic; phosphorylation; programmed cell death; programmed necrosis; pseudokinase
- Research Division(s)
- Inflammation
- PubMed ID
- 35750616
- Publisher's Version
- https://doi.org/10.1016/j.tcb.2022.05.008
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2022-07-04 08:56:57
Last Modified: 2022-07-04 08:58:24