Amyloid-beta (Abeta)-related cerebral amyloid angiopathy causing lobar hemorrhage decades after childhood neurosurgery
- Author(s)
- Kellie, JF; Campbell, BCV; Watson, R; Praeger, AJ; Nair, G; Murugasu, A; Rowe, CC; Masters, CL; Collins, S; McLean, C; Yassi, N;
- Journal Title
- Stroke
- Publication Type
- epub ahead of print
- Abstract
- BACKGROUND: Recent reports raise the possibility of cerebral amyloid angiopathy (CAA) leading to intracerebral hemorrhage in young adults following childhood neurosurgery, suggesting transmission of amyloid-beta (Abeta) through neurosurgical procedures including dura mater grafting. Parenchymal Abeta deposition, and to a lesser extent tau aggregation, similar to that seen in Alzheimer disease, have also been described. METHODS: We conducted a database review of 634 consecutive intracerebral hemorrhage patients aged <65 years at a tertiary stroke center over 20 years to identify such patients. RESULTS: We identified 3 patients aged in their thirties who presented with spontaneous lobar intracerebral hemorrhage, with imaging or neuropathology consistent with CAA, and a history of childhood neurosurgery. Two of these patients had undergone a dural repair using cadaveric dura mater (Lyodura). In addition to CAA, both patients had neuropathologically confirmed parenchymal Abeta and tau deposits, characteristic of Alzheimer disease. CONCLUSIONS: Our findings support the concept of neurosurgical Abeta transmission but suggest that such cases are rare in standard clinical practice.
- Publisher
- AHA
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 35770667
- Publisher's Version
- https://doi.org/10.1161/STROKEAHA.121.038364
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2022-07-04 08:56:58
Last Modified: 2022-07-04 09:00:58