Cell death in skin function, inflammation, and disease
- Author(s)
- Anderton, H; Alqudah, S;
- Details
- Publication Year 2022-08-12,Volume 479,Issue #15,Page 1621-1651
- Journal Title
- Biochemical Journal
- Abstract
- Cell death is an essential process that plays a vital role in restoring and maintaining skin homeostasis. It supports recovery from acute injury and infection and regulates barrier function and immunity. Cell death can also provoke inflammatory responses. Loss of cell membrane integrity with lytic forms of cell death can incite inflammation due to the uncontrolled release of cell contents. Excessive or poorly regulated cell death is increasingly recognised as contributing to cutaneous inflammation. Therefore, drugs that inhibit cell death could be used therapeutically to treat certain inflammatory skin diseases. Programmes to develop such inhibitors are already underway. In this review, we outline the mechanisms of skin-associated cell death programmes; apoptosis, necroptosis, pyroptosis, NETosis, and the epidermal terminal differentiation programme, cornification. We discuss the evidence for their role in skin inflammation and disease and discuss therapeutic opportunities for targeting the cell death machinery.
- Publisher
- Portland Press
- Keywords
- apoptosis; cell death; cornification; necroptosis; pyroptosis; skin
- Research Division(s)
- Inflammation
- PubMed ID
- 35929827
- Publisher's Version
- https://doi.org/10.1042/bcj20210606
- Open Access at Publisher's Site
https://doi.org/10.1042/BCJ20210606.- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2022-08-08 09:15:37
Last Modified: 2022-08-08 09:18:54