Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes
Details
Publication Year 2022-08-05,Volume 8,Issue #31,Page eabn4002
Journal Title
Science Advances
Abstract
Trained immunity describes the capacity of innate immune cells to develop heterologous memory in response to certain exogenous exposures. This phenomenon mediates, at least in part, the beneficial off-target effects of the BCG vaccine. Using an in vitro model of trained immunity, we show that BCG exposure induces a persistent change in active histone modifications, DNA methylation, transcription, and adenosine-to-inosine RNA modification in human monocytes. By profiling DNA methylation of circulating monocytes from infants in the MIS BAIR clinical trial, we identify a BCG-associated DNA methylation signature that persisted more than 12 months after neonatal BCG vaccination. Genes associated with this epigenetic signature are involved in viral response pathways, consistent with the reported off-target protection against viral infections in neonates, adults, and the elderly. Our findings indicate that the off-target effects of BCG in infants are accompanied by epigenetic remodeling of circulating monocytes that lasts more than 1 year.
Publisher
AAAS
WEHI Research Division(s)
Population Health And Immunity
PubMed ID
35930640
Open Access at Publisher's Site
https://doi.org/10.1126/sciadv.abn4002
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2022-08-08 09:15:40
Last Modified: 2022-08-08 09:26:00
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