A CRISPR upgrade unlocks Toxoplasma gene function
- Author(s)
- Tsee Dawson, A; Tonkin, CJ;
- Journal Title
- Trends in Parasitology
- Publication Type
- epub ahead of print
- Abstract
- Forward genetic screens are invaluable in describing gene function. CRISPR has reinvigorated phenotypic screens in Toxoplasma - a model apicomplexan parasite. Two recent papers by Smith et al. and Li et al. take the next big leap in performing forward genetic screens in Toxoplasma by combining conditional gene regulation with CRISPR.
- Publisher
- Cell Press
- Keywords
- Apicomplexa; Crispr; Toxoplasma; auxin-inducible degron; phenotypic screening; split Cas9
- Research Division(s)
- Infectious Diseases And Immune Defence; Advanced Technology And Biology
- PubMed ID
- 35973902
- Publisher's Version
- https://doi.org/10.1016/j.pt.2022.07.007
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2022-08-19 09:30:36
Last Modified: 2022-08-19 09:37:35