Platelet intrinsic apoptosis
- Author(s)
- Josefsson, EC;
- Journal Title
- Thrombosis Research
- Abstract
- In a healthy individual, the lifespan of most platelets is tightly regulated by intrinsic, or mitochondrial, apoptosis. This is a special form of programmed cell death governed by the BCL-2 family of proteins, where the prosurvival protein BCL-X(L) maintains platelet viability by restraining the prodeath proteins BAK and BAX. Restriction of platelet lifespan by activation of BAK and BAX mediated intrinsic apoptosis is essential to maintain a functional, haemostatically reactive platelet population. This review focuses on the molecular regulation of intrinsic apoptosis in platelets, reviews conditions linked to enhanced platelet death, discusses ex vivo storage of platelets and describes caveats associated with the assessment of platelet apoptosis.
- Publisher
- Elsevier
- Keywords
- Apoptosis; Bcl-x(l); Cell death; Lifespan; Mitochondria; Platelet
- Research Division(s)
- Cancer Biology And Stem Cells
- PubMed ID
- 36739256/
- Publisher's Version
- https://doi.org/10.1016/j.thromres.2022.11.024
- Open Access at Publisher's Site
https://doi.org/10.1016/j.thromres.2022.11.024- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-03-17 11:09:09
Last Modified: 2023-11-20 03:27:29