The interweaved signatures of common-gamma-chain cytokines across immunologic lineages

Baysoy, A; Seddu, K; Salloum, T; Dawson, CA; Lee, JJ; Yang, L; Gal-Oz, S; Ner-Gaon, H; Tellier, J; Millan, A; Sasse, A; Brown, B; Lanier, LL; Shay, T; Nutt, S; Dwyer, D; Benoist, C

Author(s): Baysoy, A; Seddu, K; Salloum, T; Dawson, CA; Lee, JJ; Yang, L; Gal-Oz, S; Ner-Gaon, H; Tellier, J; Millan, A; Sasse, A; Brown, B; Lanier, LL; Shay, T; Nutt, S; Dwyer, D; Benoist, C;
Details: Publication Year 2023-07-03,Volume 220,Issue #7,Page e20222052
Journal Title: Journal of Experimental Medicine
Abstract: "γc" cytokines are a family whose receptors share a "common-gamma-chain" signaling moiety, and play central roles in differentiation, homeostasis, and communications of all immunocyte lineages. As a resource to better understand their range and specificity of action, we profiled by RNAseq the immediate-early responses to the main γc cytokines across all immunocyte lineages. The results reveal an unprecedented landscape: broader, with extensive overlap between cytokines (one cytokine doing in one cell what another does elsewhere) and essentially no effects unique to any one cytokine. Responses include a major downregulation component and a broad Myc-controlled resetting of biosynthetic and metabolic pathways. Various mechanisms appear involved: fast transcriptional activation, chromatin remodeling, and mRNA destabilization. Other surprises were uncovered: IL2 effects in mast cells, shifts between follicular and marginal zone B cells, paradoxical and cell-specific cross-talk between interferon and γc signatures, or an NKT-like program induced by IL21 in CD8+ T cells
Research Division(s): Immunology
PubMed ID: 36976164
Publisher's Version: https://doi.org/10.1084/jem.20222052
Open Access at Publisher's Site: https://doi.org/10.1084/jem.20222052
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-04-13 11:09:48

Last Modified: 2023-04-13 11:36:34