Taurine deficiency as a driver of aging

Singh, P; Gollapalli, K; Mangiola, S; Schranner, D; Yusuf, MA; Chamoli, M; Shi, SL; Lopes Bastos, B; Nair, T; Riermeier, A; Vayndorf, EM; Wu, JZ; Nilakhe, A; Nguyen, CQ; Muir, M; Kiflezghi, MG; Foulger, A; Junker, A; Devine, J; Sharan, K; Chinta, SJ; Rajput, S; Rane, A; Baumert, P; Sch&#246;nfelder, M; Iavarone, F; di Lorenzo, G; Kumari, S; Gupta, A; Sarkar, R; Khyriem, C; Chawla, AS; Sharma, A; Sarper, N; Chattopadhyay, N; Biswal, BK; Settembre, C; Nagarajan, P; Targoff, KL; Picard, M; Gupta, S; Velagapudi, V; Papenfuss, AT; Kaya, A; Ferreira, MG; Kennedy, BK; Andersen, JK; Lithgow, GJ; Ali, AM; Mukhopadhyay, A; Palotie, A; Kastenm&#252;ller, G; Kaeberlein, M; Wackerhage, H; Pal, B; Yadav, VK

Author(s): Singh, P; Gollapalli, K; Mangiola, S; Schranner, D; Yusuf, MA; Chamoli, M; Shi, SL; Lopes Bastos, B; Nair, T; Riermeier, A; Vayndorf, EM; Wu, JZ; Nilakhe, A; Nguyen, CQ; Muir, M; Kiflezghi, MG; Foulger, A; Junker, A; Devine, J; Sharan, K; Chinta, SJ; Rajput, S; Rane, A; Baumert, P; Schönfelder, M; Iavarone, F; di Lorenzo, G; Kumari, S; Gupta, A; Sarkar, R; Khyriem, C; Chawla, AS; Sharma, A; Sarper, N; Chattopadhyay, N; Biswal, BK; Settembre, C; Nagarajan, P; Targoff, KL; Picard, M; Gupta, S; Velagapudi, V; Papenfuss, AT; Kaya, A; Ferreira, MG; Kennedy, BK; Andersen, JK; Lithgow, GJ; Ali, AM; Mukhopadhyay, A; Palotie, A; Kastenmüller, G; Kaeberlein, M; Wackerhage, H; Pal, B; Yadav, VK;
Details: Publication Year 2023-06-09,Volume 380,Issue #6649,Page eabn9257
Journal Title: Science
Abstract: Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
Publisher: AAAS
Keywords: Humans; Mice; Animals; *Aging; Longevity; Cellular Senescence; Taurine; *Malnutrition; Haplorhini
Research Division(s): Bioinformatics
PubMed ID: 37289866
Publisher's Version: https://doi.org/10.1126/science.abn9257
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-06-30 02:16:21

Last Modified: 2023-06-30 03:04:04