A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
- Author(s)
- Muhi, S; Osowicki, J; O'Brien, D; Johnson, PDR; Pidot, S; Doerflinger, M; Marshall, JL; Pellegrini, M; Mccarthy, J; Stinear, TP;
- Details
- Publication Year 2023-06,Volume 17,Issue #6,Page e0011394
- Journal Title
- PLoS Neglected Tropical Diseases
- Abstract
- Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.
- Publisher
- PLOS
- Research Division(s)
- Infectious Diseases And Immune Defence
- PubMed ID
- 37384606
- Publisher's Version
- https://doi.org/10.1371/journal.pntd.0011394
- Open Access at Publisher's Site
https://doi.org/10.1371/journal.pntd.0011394- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-07-12 08:04:58
Last Modified: 2023-07-12 08:17:37