A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
Details
Publication Year 2023-06,Volume 17,Issue #6,Page e0011394
Journal Title
PLoS Neglected Tropical Diseases
Abstract
Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.
Publisher
PLOS
Research Division(s)
Infectious Diseases And Immune Defence
PubMed ID
37384606
Open Access at Publisher's Site
https://doi.org/10.1371/journal.pntd.0011394
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-07-12 08:04:58
Last Modified: 2023-07-12 08:17:37
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