Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan
Details
Publication Year 2023-05-04,Volume 56,Issue #7,Page 1596-1612 e4
Journal Title
Immunity
Abstract
Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and persistence using a genetic reporter to time-stamp ASCs. This approach revealed ASC lifespans as heterogeneous and falling on a continuum, with only a small fraction surviving for >60 days. ASC longevity past 60 days was independent of isotype but correlated with a phenotype that developed progressively and ultimately associated with an underlying "long-lived" ASC (LL ASC)-enriched transcriptional program. While some of the differences between LL ASCs and other ASCs appeared to be acquired with age, other features were shared with some younger ASCs, such as high CD138 and CD93. Turnover was unaffected by altered ASC production, arguing against competition for niches as a major driver of turnover. Thus, ASC turnover is set by intrinsic lifespan limits, with steady-state population dynamics governed by niche vacancy rather than displacement.
Publisher
Cell Press
Keywords
Mcl1; antibody; antibody-producing cell; competition; niche; plasma cell; plasmablast; rituximab; survival; turnover
Research Division(s)
Immunology
PubMed ID
37164016
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-07-21 09:50:17
Last Modified: 2023-07-21 09:52:18
An error has occurred. This application may no longer respond until reloaded. Reload 🗙