Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS)
Journal Title
Blood Reviews
Abstract
The guidelines for classification, prognostication, and response assessment of myelodysplastic syndromes/neoplasms (MDS) have all recently been updated. In this report on behalf of the International Consortium for MDS (icMDS) we summarize these developments. We first critically examine the updated World Health Organization (WHO) classification and the International Consensus Classification (ICC) of MDS. We then compare traditional and molecularly based risk MDS risk assessment tools. Lastly, we discuss limitations of criteria in measuring therapeutic benefit and highlight how the International Working Group (IWG) 2018 and 2023 response criteria addressed these deficiencies and are endorsed by the icMDS. We also address the importance of patient centered care by discussing the value of quality-of-life assessment. We hope that the reader of this review will have a better understanding of how to classify MDS, predict clinical outcomes and evaluate therapeutic outcomes.
Publisher
Elsevier
Keywords
Diagnostic criteria; Ipss-m; Mds; Myelodysplastic syndrome; Novel therapies; Risk classification
Research Division(s)
Blood Cells And Blood Cancer
PubMed ID
37704469
Open Access at Publisher's Site
https://doi.org/10.1016/j.blre.2023.101128
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-09-21 11:41:20
Last Modified: 2023-12-13 10:19:48
An error has occurred. This application may no longer respond until reloaded. Reload 🗙