Chronic lymphocytic leukaemia Australasian consensus practice statement

Anderson, MA; Bennett, R; Badoux, X; Best, G; Chia, N; Cochrane, T; Cull, G; Crassini, K; Harrup, R; Jackson, S; Kuss, B; Lasica, M; Lew, TE; Marlton, P; Opat, S; Palfreyman, E; Polizzotto, MN; Ratnasingam, S; Seymour, JF; Soosapilla, A; Talaulikar, D; Tam, CS; Weinkove, R; Wight, J; Mulligan, SP

Author(s): Anderson, MA; Bennett, R; Badoux, X; Best, G; Chia, N; Cochrane, T; Cull, G; Crassini, K; Harrup, R; Jackson, S; Kuss, B; Lasica, M; Lew, TE; Marlton, P; Opat, S; Palfreyman, E; Polizzotto, MN; Ratnasingam, S; Seymour, JF; Soosapilla, A; Talaulikar, D; Tam, CS; Weinkove, R; Wight, J; Mulligan, SP;
Details: Publication Year 2023-09,Volume 53,Issue #9,Page 1678-1691
Journal Title: Internal Medicine Journal
Abstract: Chronic lymphocytic leukaemia (CLL) is the most common haematological malignancy in Australia and New Zealand (ANZ). Considerable changes to diagnostic and management algorithms have occurred within the last decade. The availability of next-generation sequencing and measurable residual disease assessment by flow cytometry allow for advanced prognostication and response assessments. Novel therapies, including inhibitors of Bruton's tyrosine kinase (BTKi) and B-cell lymphoma 2 (BCL2) inhibitors, have transformed the treatment landscape for both treatment-naïve and relapsed/refractory disease, particularly for patients with high-risk genetic aberrations. Recommendations regarding appropriate supportive management continue to evolve, and special considerations are required for patients with CLL with respect to the global SARS-CoV-2 pandemic. The unique funding and treatment environments in Australasia highlight the need for specific local guidance with respect to the investigation and management of CLL. This consensus practice statement was developed by a broadly representative group of ANZ experts in CLL with endorsement by peak haematology bodies, with a view to providing this standardised guidance.
Publisher: Wiley
Keywords: Humans; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/genetics/therapy; Consensus; *ovid-19; SARS-CoV-2; Hematologic Neoplasms; Cll; diagnosis; management
Research Division(s): Blood Cells And Blood Cancer
PubMed ID: 37743239
Publisher's Version: https://doi.org/10.1111/imj.16207
Open Access at Publisher's Site: https://doi.org/10.1111/imj.16207
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-09-27 08:47:31

Last Modified: 2023-09-27 08:56:44