Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study
- Author(s)
- Franks, KH; Cribb, L; Bransby, L; Buckley, R; Yassi, N; Chong, TT; Lim, YY; Pase, MP;
- Details
- Publication Year 2023,Volume 7,Issue #1,Page 1025-1031
- Journal Title
- Journal of Alzheimer’s DIsease Reports
- Abstract
- Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β(42), phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f(2) effect sizes were small in magnitude (f(2)≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.
- Publisher
- IOS Press
- Keywords
- Alzheimer’s disease; amyloid; biomarkers; dementia; psychological stress
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 37849635
- Publisher's Version
- https://doi.org/10.3233/adr-230052
- Open Access at Publisher's Site
https://doi.org/10.3233/adr-230052- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-11-15 05:00:07
Last Modified: 2023-11-15 05:22:57