A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development

O&#39;Keefe, RN; Carli, ALE; Baloyan, D; Chisanga, D; Shi, W; Afshar-Sterle, S; Eissmann, MF; Poh, AR; Pal, B; Seillet, C; Locksley, RM; Ernst, M; Buchert, M

Author(s): O'Keefe, RN; Carli, ALE; Baloyan, D; Chisanga, D; Shi, W; Afshar-Sterle, S; Eissmann, MF; Poh, AR; Pal, B; Seillet, C; Locksley, RM; Ernst, M; Buchert, M;
Details: Publication Year 2023-10-28,Volume 14,Issue #1,Page 6872
Journal Title: Nature Communications
Abstract: Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties of the crosstalk between intestinal tuft cells and type 2 innate lymphoid cells (ILC2) that is evolutionarily optimized for epithelial remodeling in response to helminth infection. We demonstrate that tuft cell-derived interleukin 25 (IL25) drives ILC2 activation, inducing the release of IL13 and promoting epithelial tuft cell hyperplasia. While the resulting tuft cell - ILC2 feed-forward circuit promotes gastric metaplasia and tumor formation, genetic depletion of tuft cells or ILC2s, or therapeutic targeting of IL13 or IL25 alleviates these pathologies in mice. In gastric cancer patients, tuft cell and ILC2 gene signatures predict worsening survival in intestinal-type gastric cancer where ~40% of the corresponding cancers show enriched co-existence of tuft cells and ILC2s. Our findings suggest a role for ILC2 and tuft cells, along with their associated cytokine IL13 and IL25 as gatekeepers and enablers of metaplastic transformation and gastric tumorigenesis, thereby providing an opportunity to therapeutically inhibit early-stage gastric cancer through repurposing antibody-mediated therapies.
Publisher: NPG
Keywords: Humans; Mice; Animals; *Immunity, Innate; Interleukin-13/metabolism; *Stomach Neoplasms/pathology; Lymphocytes/metabolism; Hyperplasia/metabolism; Metaplasia/metabolism
Research Division(s): Immunology
PubMed ID: 37898600
Publisher's Version: https://doi.org/10.1038/s41467-023-42215-4
Open Access at Publisher's Site: https://doi.org/10.1038/s41467-023-42215-4
Terms of Use/Rights Notice: Refer to copyright notice on published article.
Documents: s41467-023-42215-4.pdf - (2.78MB, application/pdf)

Creation Date: 2023-11-20 12:03:36

Last Modified: 2023-11-20 12:07:19