Chromatin-mediated silencing on the inactive X chromosome
- Author(s)
- Keniry, A; Blewitt, ME;
- Journal Title
- Development
- Abstract
- In mammals, the second X chromosome in females is silenced to enable dosage compensation between XX females and XY males. This essential process involves the formation of a dense chromatin state on the inactive X (Xi) chromosome. There is a wealth of information about the hallmarks of Xi chromatin and the contribution each makes to silencing, leaving the tantalising possibility of learning from this knowledge to potentially remove silencing to treat X-linked diseases in females. Here, we discuss the role of each chromatin feature in the establishment and maintenance of the silent state, which is of crucial relevance for such a goal.
- Publisher
- COB
- Keywords
- Male; Animals; Female; *X Chromosome Inactivation/genetics; *RNA, Long Noncoding/genetics; X Chromosome/genetics; Chromatin/genetics; Dosage Compensation, Genetic; Mammals/genetics; Epigenetics; Gene silencing; Stem cells; X inactivation
- Research Division(s)
- Epigenetics And Development
- Publisher's Version
- https://doi.org/10.1242/dev.201742
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-11-30 09:13:29
Last Modified: 2023-11-30 09:29:07