TRAPs: the 'elevator-with-an-operator' mechanism
- Author(s)
- Davies, JS; Currie, MJ; Dobson, RCJ; Horne, CR; North, RA;
- Details
- Publication Year 2023-12-14,Volume 49,Issue #2,Page 134-144
- Journal Title
- Trends in Biochemical Sciences
- Abstract
- Tripartite ATP-independent periplasmic (TRAP) transporters are nutrient-uptake systems found in bacteria and archaea. These evolutionary divergent transporter systems couple a substrate-binding protein (SBP) to an elevator-type secondary transporter, which is a first-of-its-kind mechanism of transport. Here, we highlight breakthrough TRAP transporter structures and recent functional data that probe the mechanism of transport. Furthermore, we discuss recent structural and biophysical studies of the ion transporter superfamily (ITS) members and highlight mechanistic principles that are relevant for further exploration of the TRAP transporter system.
- Publisher
- Cell Press
- Keywords
- ion transporter superfamily; membrane proteins; secondary transporters; sialic acid; transport mechanism; tripartite ATP-independent periplasmic (TRAP) transporters
- Research Division(s)
- Inflammation
- PubMed ID
- 38102017
- Publisher's Version
- https://doi.org/10.1016/j.tibs.2023.11.006
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-12-21 07:38:36
Last Modified: 2024-03-05 09:29:06