Unraveling the diversity and functions of tissue-resident plasma cells
- Author(s)
- Tellier, J; Tarasova, I; Nie, J; Smillie, CS; Fedele, PL; Cao, WHJ; Groom, JR; Belz, GT; Bhattacharya, D; Smyth, GK; Nutt, SL;
- Details
- Publication Year 2024-01-03,Volume 25,Issue #2,Page 330-342
- Journal Title
- Nature Immunology
- Abstract
- Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative of functional adaptation to the host tissue environment. In contrast to expectation, all TrPCs were extremely long-lived, regardless of their organ of residence, with longevity influenced by intrinsic factors like the immunoglobulin isotype. Analysis at single-cell resolution revealed that the bone marrow is unique in housing a compendium of PCs generated all over the body that retain aspects of the transcriptional program indicative of their tissue of origin. This study reveals that extreme longevity is an intrinsic property of TrPCs whose transcriptome is imprinted by signals received both at the site of induction and within the tissue of residence.
- Publisher
- NPG
- Keywords
- *Plasma Cells; *Bone Marrow; Bone Marrow Cells
- Research Division(s)
- Immunology; Bioinformatics; Bioinformatics
- PubMed ID
- 38172260
- Publisher's Version
- https://doi.org/10.1038/s41590-023-01712-w
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-01-25 09:18:11
Last Modified: 2024-03-11 09:39:16