Neisseria gonorrhoeae vaccines: a contemporary overview

Williams, E; Seib, KL; Fairley, CK; Pollock, GL; Hocking, JS; McCarthy, JS; Williamson, DA

Author(s): Williams, E; Seib, KL; Fairley, CK; Pollock, GL; Hocking, JS; McCarthy, JS; Williamson, DA;
Details: Publication Year 2024-01-16,Volume 37,Issue #1,Page e0009423
Journal Title: Clinical Microbiology Reviews
Abstract: SUMMARYNeisseria gonorrhoeae infection is an important public health issue, with an annual global incidence of 87 million. N. gonorrhoeae infection causes significant morbidity and can have serious long-term impacts on reproductive and neonatal health and may rarely cause life-threatening disease. Global rates of N. gonorrhoeae infection have increased over the past 20 years. Importantly, rates of antimicrobial resistance to key antimicrobials also continue to increase, with the United States Centers for Disease Control and Prevention identifying drug-resistant N. gonorrhoeae as an urgent threat to public health. This review summarizes the current evidence for N. gonorrhoeae vaccines, including historical clinical trials, key N. gonorrhoeae vaccine preclinical studies, and studies of the impact of Neisseria meningitidis vaccines on N. gonorrhoeae infection. A comprehensive survey of potential vaccine antigens, including those identified through traditional vaccine immunogenicity approaches, as well as those identified using more contemporary reverse vaccinology approaches, are also described. Finally, the potential epidemiological impacts of a N. gonorrhoeae vaccine and research priorities for further vaccine development are described.
Publisher: CMR
Keywords: Neisseria gonorrhoeae; Neisseria meningitidis; controlled human infection model; public health; sexually transmitted diseases; vaccines
Research Division(s): Infectious Diseases And Immune Defence
PubMed ID: 38226640
Publisher's Version: https://doi.org/10.1128/cmr.00094-23
Open Access at Publisher's Site: https://doi.org/10.1128/cmr.00094-23
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-01-25 09:18:12

Last Modified: 2024-03-18 02:09:49