Impaired IgM Memory B Cell Function Is Common in Coeliac Disease but Conjugate Pneumococcal Vaccination Induces Robust Protective Immunity

Moscatelli, OG; Russell, AK; Henneken, LM; Hardy, MY; Mazarakis, N; Higgins, R; Ekin, J; McLeod, H; Simkin, P; Licciardi, PV; Bryant, VL; Tye-Din, JA

Author(s): Moscatelli, OG; Russell, AK; Henneken, LM; Hardy, MY; Mazarakis, N; Higgins, R; Ekin, J; McLeod, H; Simkin, P; Licciardi, PV; Bryant, VL; Tye-Din, JA;
Details: Publication Year 2024-02-19,Volume 12,Issue #2,Page 214
Journal Title: Vaccines
Abstract: Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little is known about the immune implications of hyposplenism in CD or the optimal pneumococcal vaccination strategy. In this study, the immune effects of hyposplenism in CD, and the accuracy of screening approaches and protective responses induced by two different pneumococcal vaccines were examined. Active and treated CD cohorts, and healthy and surgically splenectomised controls underwent testing for the presence of Howell-Jolly bodies and pitted red cells, spleen ultrasound, and immune assessment of IgM memory B cell frequency and IgM memory B cell responses to T cell-dependent (TD) or T cell-independent (TI) stimulation. Responses following conjugate (TD) and polysaccharide (TI) pneumococcal vaccination were compared using ELISA and opsonophagocytic assays. Although hyposplenism is rare in treated CD (5.1%), functional B cell defects are common (28-61%) and are not detected by current clinical tests. Conjugate pneumococcal vaccination induced superior and sustained protection against clinically relevant serotypes. Clinical practice guidelines in CD should recommend routine pneumococcal vaccination, ideally with a conjugate vaccine, of all patients in lieu of hyposplenism screening.
Publisher: MDPI
Keywords: IgM memory B cells; coeliac disease; hyposplenism; pneumococcal vaccination
Research Division(s): Immunology
PubMed ID: 38400197
Publisher's Version: https://doi.org/10.3390/vaccines12020214
Open Access at Publisher's Site: https://doi.org/ 10.3390/vaccines12020214
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-02-29 09:16:15

Last Modified: 2024-02-29 09:22:52