Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF
- Author(s)
- O'Sullivan, JF; Li, M; Koay, YC; Wang, XS; Guglielmi, G; Marques, FZ; Nanayakkara, S; Mariani, J; Slaughter, E; Kaye, DM;
- Details
- Publication Year 2024,Volume 9,Issue #3,Page 281-299
- Journal Title
- JACC: Basic to Translational Science
- Abstract
- The authors conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified. © 2024 The Authors
- Publisher
- Elsevier
- Keywords
- cardiac energetics; heart failure with preserved ejection fraction; invasive hemodynamics; lipids
- Research Division(s)
- Bioinformatics
- Publisher's Version
- https://doi.org/10.1016/j.jacbts.2023.11.006
- Open Access at Publisher's Site
https://doi.org/10.1016/j.jacbts.2023.11.006- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-03-27 08:35:45
Last Modified: 2024-03-27 08:49:08