Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey

Yoshida, A; Li, Y; Maroufy, V; Kuwana, M; Sazliyana Shaharir, S; Makol, A; Sen, P; Lilleker, JB; Agarwal, V; Kadam, E; Akawatcharangura Goo, P; Day, J; Milchert, M; Chen, YM; Dey, D; Velikova, T; Saha, S; Edgar Gracia-Ramos, A; Parodis, I; Nikiphorou, E; Tan, AL; Nune, A; Cavagna, L; Toro Guti&#233;rrez, CE; Caballero-Uribe, CV; Saavedra, MA; Shinjo, SK; Ziade, N; El Kibbi, L; Knitza, J; Distler, O; Chinoy, H; Agarwal, V; Aggarwal, R; Gupta, L

Author(s): Yoshida, A; Li, Y; Maroufy, V; Kuwana, M; Sazliyana Shaharir, S; Makol, A; Sen, P; Lilleker, JB; Agarwal, V; Kadam, E; Akawatcharangura Goo, P; Day, J; Milchert, M; Chen, YM; Dey, D; Velikova, T; Saha, S; Edgar Gracia-Ramos, A; Parodis, I; Nikiphorou, E; Tan, AL; Nune, A; Cavagna, L; Toro Gutiérrez, CE; Caballero-Uribe, CV; Saavedra, MA; Shinjo, SK; Ziade, N; El Kibbi, L; Knitza, J; Distler, O; Chinoy, H; Agarwal, V; Aggarwal, R; Gupta, L;
Details: Publication Year 2024,Volume 8,Issue #2,Page rkae028
Journal Title: Rheumatology Advances in Practice
Abstract: OBJECTIVES: To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database. METHODS: Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores. Factors affecting GPH and GMH scores in IIMs were identified using multivariable regression analysis. RESULTS: We analysed responses from 1582 IIM, 4700 non-IIM AIRD and 545 nrAID patients and 3675 controls gathered through 23 May 2022. The median GPH scores were the lowest in IIM and non-IIM AIRD patients {13 [interquartile range (IQR) 10-15] IIMs vs 13 [11-15] non-IIM AIRDs vs 15 [13-17] nrAIDs vs 17 [15-18] controls, P < 0.001}. The median GMH scores in IIM patients were also significantly lower compared with those without autoimmune diseases [13 (IQR 10-15) IIMs vs 15 (13-17) controls, P < 0.001]. Inclusion body myositis, comorbidities, active disease and glucocorticoid use were the determinants of lower GPH scores, whereas overlap myositis, interstitial lung disease, depression, active disease, lower PROMIS Physical Function 10a and higher PROMIS Fatigue 4a scores were associated with lower GMH scores in IIM patients. CONCLUSION: Both physical and mental health are significantly impaired in IIM patients, particularly in those with comorbidities and increased fatigue, emphasizing the importance of patient-reported experiences and optimized multidisciplinary care to enhance well-being in people with IIMs.
Publisher: Oxford Academic
Keywords: e-survey; myositis; patient-reported outcome measures; quality of life
Research Division(s): Inflammation
PubMed ID: 38524696
Publisher's Version: https://doi.org/10.1093/rap/rkae028
Open Access at Publisher's Site: https://doi.org/10.1093/rap/rkae028
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-03-27 08:35:49

Last Modified: 2024-03-27 08:50:21