Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer
- Author(s)
- Dagley, LF; Yousef, J; Preaudet, A; Loving, A; Webb, AI; Ernst, M; Putoczki, TL;
- Details
- Publication Year 2024-03-08,Volume 25,Issue #6,Page 3129
- Journal Title
- International Journal of Molecular Sciences
- Abstract
- There are a limited number of clinically useful serum biomarkers to predict tumor onset or treatment response in gastric cancer (GC). For this reason, we explored the serum proteome of the gp130(Y757F) murine model of intestinal-type gastric cancer (IGC). We identified 30 proteins with significantly elevated expression in early gp130(Y757F) IGC and 12 proteins that were significantly elevated in late gp130(Y757F) IGC compared to age- and gender-matched wild-type mice. Within these signatures, there was an overlap of 10 proteins commonly elevated in both early- and late-stage disease. These results highlight the potential to identify serum biomarkers of disease stage. Since IGC in the gp130(Y757F) model can be reversed following therapeutic inhibition of Interleukin (IL)-11, we explored whether the protein signatures we identified could be used to monitor tumor regression. We compared two different therapeutic modalities and found 5 proteins to be uniquely differentially expressed between control animals and animals halfway through treatment, with 10 differentially expressed at the end of treatment. Our findings highlight the potential to identify reliable biomarkers to track IGC tumor regression in response to treatment.
- Publisher
- MDPI
- Keywords
- Mice; Animals; *Signal Transduction/physiology; *Stomach Neoplasms/pathology; Cytokine Receptor gp130/metabolism; Biomarkers; Biomarkers, Tumor; Interleukin-11; biomarker; intestinal-type gastric cancer; mouse model; proteomics
- Research Division(s)
- Personalised Oncology; Advanced Technology And Biology
- PubMed ID
- 38542101
- Publisher's Version
- https://doi.org/10.3390/ijms25063129
- Open Access at Publisher's Site
https://doi.org/10.3390/ijms25063129- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-04-08 12:14:49
Last Modified: 2024-04-08 12:25:03