Eosinophils in Oral Disease: A Narrative Review

Al-Azzawi, HMA; Paolini, R; Cirillo, N; O&#39;Reilly, LA; Mormile, I; Moore, C; Yap, T; Celentano, A

Author(s): Al-Azzawi, HMA; Paolini, R; Cirillo, N; O'Reilly, LA; Mormile, I; Moore, C; Yap, T; Celentano, A;
Details: Publication Year 2024-04-16,Volume 25,Issue #8,Page 4373
Journal Title: International journal of Molecular Sciences
Abstract: The prevalence of diseases characterised by eosinophilia is on the rise, emphasising the importance of understanding the role of eosinophils in these conditions. Eosinophils are a subset of granulocytes that contribute to the body's defence against bacterial, viral, and parasitic infections, but they are also implicated in haemostatic processes, including immunoregulation and allergic reactions. They contain cytoplasmic granules which can be selectively mobilised and secrete specific proteins, including chemokines, cytokines, enzymes, extracellular matrix, and growth factors. There are multiple biological and emerging functions of these specialised immune cells, including cancer surveillance, tissue remodelling and development. Several oral diseases, including oral cancer, are associated with either tissue or blood eosinophilia; however, their exact mechanism of action in the pathogenesis of these diseases remains unclear. This review presents a comprehensive synopsis of the most recent literature for both clinicians and scientists in relation to eosinophils and oral diseases and reveals a significant knowledge gap in this area of research.
Keywords: Humans; *Eosinophils/immunology/metabolism; *Mouth Diseases/immunology/pathology; Animals; Eosinophilia/immunology/metabolism/pathology; Cytokines/metabolism; eosinophils; oral cancer; oral diseases; oral potentially malignant disorders
Research Division(s): Inflammation
PubMed ID: 38673958
Publisher's Version: https://doi.org/10.3390/ijms25084373
Open Access at Publisher's Site: https://doi.org/10.3390/ijms25084373
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-05-08 10:06:30

Last Modified: 2024-05-08 10:16:42