Budesonide Induces Favourable Histologic and Symptomatic Recovery in Patients with Non-responsive and Refractory Coeliac Disease When Given in an Open Capsule Format
- Author(s)
- Saitta, D; Henneken, LM; Apputhurai, P; Chen Yi Mei, SL; Tye-Din, JA;
- Journal Title
- Digestive Diseases and Sciences
- Publication Type
- Aprl 29 epub ahead of print
- Abstract
- INTRODUCTION: Non-responsive disease (NRCD), where symptoms and enteropathy persist despite a prolonged gluten-free diet (GFD), is common. Refractory coeliac disease (RCD), characterised by malabsorption and extensive enteropathy, is rare but serious. In both, treatment options are limited. Topical budesonide may help and an open capsule format promoting proximal small intestinal delivery may be advantageous. AIM: To describe the effect of budesonide and its presentation on mucosal healing, symptoms, and tolerability in NRCD and RCD. METHODS: A retrospective cohort study of NRCD and RCD patients who received budesonide for enteropathy despite a strict GFD for over 12 months. Primary outcome was improvement in histology. Symptoms and adverse treatment effects were recorded. RESULTS: 50 patients with NRCD (n = 14; 86% F), RCD type 1 (n = 30; 60% F), and RCD type 2 (n = 6 based on aberrant duodenal T cells; 33% F) were identified. Common RCD symptoms were diarrhoea (68%), fatigue (40%), and weight loss (34%). 16 received closed capsule budesonide (CCB) 9 mg OD and 35 open capsule budesonide (OCB) 3 mg 3 times a day. Complete and partial mucosal healing was significantly higher after OCB compared to CCB (p < 0.001, Mann-Whitney U test). Symptom improvement was also significantly higher after OCB compared to CCB (p = 0.002, Mann-Whitney U test). Side effects were mild and self-limiting and were reported in 25% of both cohorts. CONCLUSION: OCB was well tolerated and associated with improvements in enteropathy (83%) and symptoms (90%) in NRCD and RCD. Our findings support OCB as the preferred 1st-line therapy for NRCD and RCD type 1.
- Publisher
- Springer
- Keywords
- Budesonide; Gluten-free diet; Non-responsive coeliac disease; Refractory coeliac disease; coeliac disease
- Research Division(s)
- Immunology
- PubMed ID
- 38683433
- Publisher's Version
- https://doi.org/10.1007/s10620-024-08436-3
- Open Access at Publisher's Site
https://doi.org/ 10.1007/s10620-024-08436-3- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-05-08 10:06:40
Last Modified: 2024-05-08 10:40:17