The biology and pathogenesis of vivax malaria
- Author(s)
- Anstey, NM; Tham, WH; Shanks, GD; Poespoprodjo, JR; Russell, BM; Kho, S;
- Journal Title
- Trends in Parasitology
- Publication Type
- May 14 epub ahead of print
- Abstract
- Plasmodium vivax contributes significantly to global malaria morbidity. Key advances include the discovery of pathways facilitating invasion by P. vivax merozoites of nascent reticulocytes, crucial for vaccine development. Humanized mouse models and hepatocyte culture systems have enhanced understanding of hypnozoite biology. The spleen has emerged as a major reservoir for asexual vivax parasites, replicating in an endosplenic life cycle, and contributing to recurrent and chronic infections, systemic inflammation, and anemia. Splenic accumulation of uninfected red cells is the predominant cause of anemia. Recurring and chronic infections cause progressive anemia, malnutrition, and death in young children in high-transmission regions. Endothelial activation likely contributes to vivax-associated organ dysfunction. The many recent advances in vivax pathobiology should help guide new approaches to prevention and management.
- Publisher
- Cell Press
- Keywords
- Plasmodium vivax; biology; hidden biomass; life cycle; pathophysiology; spleen
- Research Division(s)
- Infectious Diseases And Immune Defence
- PubMed ID
- 38749866
- Publisher's Version
- https://doi.org/10.1016/j.pt.2024.04.015
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-05-20 07:52:11
Last Modified: 2024-06-28 10:48:08