The biology and pathogenesis of vivax malaria
Details
Publication Year 2024-07,Volume 40,Issue #7,Page 573-590
Journal Title
Trends in Parasitology
Abstract
Plasmodium vivax contributes significantly to global malaria morbidity. Key advances include the discovery of pathways facilitating invasion by P. vivax merozoites of nascent reticulocytes, crucial for vaccine development. Humanized mouse models and hepatocyte culture systems have enhanced understanding of hypnozoite biology. The spleen has emerged as a major reservoir for asexual vivax parasites, replicating in an endosplenic life cycle, and contributing to recurrent and chronic infections, systemic inflammation, and anemia. Splenic accumulation of uninfected red cells is the predominant cause of anemia. Recurring and chronic infections cause progressive anemia, malnutrition, and death in young children in high-transmission regions. Endothelial activation likely contributes to vivax-associated organ dysfunction. The many recent advances in vivax pathobiology should help guide new approaches to prevention and management.
Publisher
Cell Press
Keywords
Humans; *Malaria, Vivax/parasitology/immunology/physiopathology; Animals; *Plasmodium vivax/physiology/pathogenicity; Spleen/parasitology/physiopathology/immunology; Plasmodium vivax; biology; hidden biomass; life cycle; pathophysiology; spleen
Research Division(s)
Infectious Diseases And Immune Defence
PubMed ID
38749866
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2024-05-20 07:52:11
Last Modified: 2024-07-10 09:25:37
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