Mapping and modelling human B cell maturation in the germinal centre
- Author(s)
- Quig, A; Kriachkov, V; King, H;
- Journal Title
- Current opinion in Immunology
- Abstract
- The maturation of B cells within the germinal centre (GC) is necessary for antigen-specific immune responses and memory. Dysfunction in the GC can lead to immunodeficiencies, autoimmune diseases, or lymphomas. Here we describe how recent advances in single-cell and spatial genomics have enabled new discoveries about the diversity of human GC B cell states. However, with the advent of these hypothesis-generating technologies, the field should now transition towards testing bioinformatic predictions using experimental models of the human GC. We review available experimental culture systems for modelling human B cell responses and discuss the potential limitations of different methods in capturing bona fide GC B cell states. Together, the combination of cell atlas-based mapping with experimental modelling of lymphoid tissues holds great promise to better understand the maturation of human B cells in the GC response and generate new insights into human immune health and disease.
- Publisher
- Elsevier
- Keywords
- Humans; *Germinal Center/immunology; *B-Lymphocytes/immunology; *Cell Differentiation/immunology; Animals
- Research Division(s)
- Epigenetics And Development
- PubMed ID
- 38815421
- Publisher's Version
- https://doi.org/10.1016/j.coi.2024.102428
- Open Access at Publisher's Site
https://doi.org/10.1016/j.coi.2024.102428- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-06-24 11:29:59
Last Modified: 2024-06-24 12:14:59