Pathogenesis of Post-Tuberculosis Lung Disease: Defining Knowledge Gaps and Research Priorities at the 2(nd) International Post-Tuberculosis Symposium

Auld, SC; Barczak, AK; Bishai, W; Coussens, AK; Dewi, IMW; Mitini-Nkhoma, SC; Muefong, C; Naidoo, T; Pooran, A; Stek, C; Steyn, AJC; Tezera, L; Walker, NF

Author(s): Auld, SC; Barczak, AK; Bishai, W; Coussens, AK; Dewi, IMW; Mitini-Nkhoma, SC; Muefong, C; Naidoo, T; Pooran, A; Stek, C; Steyn, AJC; Tezera, L; Walker, NF;
Details: Publication Year 2024-08-14,Volume 210,Issue #8,Page 979-993
Journal Title: American Journal of Respiratory and Critical Care Medicine
Abstract: Post-tuberculosis (TB) lung disease (PTLD) is increasingly recognized as a major contributor to the global burden of chronic lung disease, with recent estimates indicating that over half of TB survivors have impaired lung function after successful completion of TB treatment. However, the pathologic mechanisms that contribute to PTLD are not well understood, thus limiting the development of therapeutic interventions to improve long-term outcomes after TB. This report summarizes the work of the "Pathogenesis and Risk Factors Committee" for the Second International Post-Tuberculosis Symposium, which took place in Stellenbosch, South Africa in April 2023. The committee first identified six areas with high translational potential: (1) tissue matrix destruction, including the role of matrix metalloproteinase dysregulation and neutrophil activity, (2) fibroblasts and profibrotic activity, (3) granuloma fate and cell death pathways, (4) mycobacterial factors including pathogen burden, (5) animal models, and (6) the impact of key clinical risk factors including HIV, diabetes, smoking, malnutrition, and alcohol. We share here the key findings from a literature review of those areas, highlighting knowledge gaps and areas where further research is needed.
Publisher: ATS
Keywords: fibrosis; matrix metalloproteinases; neutrophils; post-tuberculosis lung disease; tuberculosis
Research Division(s): Infectious Diseases And Immune Defence
PubMed ID: 39141569
Publisher's Version: https://doi.org/10.1164/rccm.202402-0374SO
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-08-23 02:54:12

Last Modified: 2024-10-25 10:50:48