Defining the niche for stem-like CD8(+) T cell formation and function
- Author(s)
- Broomfield, BJ; Groom, JR;
- Journal Title
- Current Opinion in Immunology
- Abstract
- TCF-1(+) CD8(+) T cell populations have emerged as critical determinants for long-lived immunological memory. This cell population has stem-like properties and is implicated in improved disease outcomes by driving sustained killing of infected cells and maintaining the immune-cancer equilibrium. During an immune response, several factors, including antigen deposition and affinity, the inflammatory milieu, and T cell priming dynamics, aggregate to skew CD8(+) T cell differentiation. Although these mechanisms are altered between acute and chronic disease settings, phenotypically similar stem-like TCF-1(+) CD8(+) T cell states are formed in each of these settings. Here, we characterize the specialized microenvironments within lymph nodes and the tumor microenvironment, which foster the generation or re-activation of stem-like TCF-1(+) CD8(+) T cell populations. We highlight the potential for targeting the stem-like CD8(+) T cell niche to enhance vaccination and cancer immunotherapy and to track the trajectory of stem-like CD8(+) T cells as biomarkers of therapeutic efficacy.
- Publisher
- Elsevier
- Research Division(s)
- Immunology
- PubMed ID
- 39154521
- Publisher's Version
- https://doi.org/10.1016/j.coi.2024.102454
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-08-23 02:54:19
Last Modified: 2024-08-23 02:56:30