TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells
- Author(s)
- Bong, AHL; Robitaille, M; Lin, S; McCart-Reed, A; Milevskiy, M; Angers, S; Roberts-Thomson, SJ; Monteith, GR;
- Details
- Publication Year 2024-10-01,Volume 10,Issue #1,Page 421
- Journal Title
- Cell Death Discovery
- Abstract
- The release of Ca(2+) ions from endoplasmic reticulum calcium stores is a key event in a variety of cellular processes, including gene transcription, migration and proliferation. This release of Ca(2+) often occurs through inositol 1,4,5-triphosphate receptors and the activity of these channels and the levels of stored Ca(2+) in the endoplasmic reticulum are important regulators of cell death in cancer cells. A recently identified Ca(2+) channel of the endoplasmic reticulum is transmembrane and coiled-coil domains 1 (TMCO1). In this study, we link the overexpression of TMCO1 with prognosis in node-positive basal breast cancer patients. We also identify interacting proteins of TMCO1, which include endoplasmic reticulum-resident proteins involved in Ca(2+) regulation and proteins directly involved in nucleocytoplasmic transport. Interacting proteins included nuclear transport proteins and TMCO1 was shown to have both nuclear and endoplasmic reticulum localisation in MDA-MB-231 basal breast cancer cells. These studies also define a role for TMCO1 in the regulation of breast cancer cells in their sensitivity to BCL-2/MCL-1 inhibitors, analogous to the role of inositol 1,4,5-triphosphate receptors in the regulation of cell death pathways activated by these agents.
- Publisher
- Springer Nature
- Research Division(s)
- Cancer Biology And Stem Cells
- PubMed ID
- 39353922
- Publisher's Version
- https://doi.org/10.1038/s41420-024-02183-0
- Open Access at Publisher's Site
https://doi.org/10.1038/s41420-024-02183-0.- Terms of Use/Rights Notice
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Creation Date: 2024-10-04 10:44:48
Last Modified: 2024-10-04 10:57:12