The impact of multimorbidity on QoL in inflammatory myopathies: COVAD cluster analysis
- Author(s)
- FORNARO, M; Venerito, V; Pellico, MR; Iannone, F; Joshi, M; Chen, YM; Tan, AL; Saha, S; Chatterjee, T; Agarwal, V; Shinjo, SK; Hoff, LS; Kadam, E; Ziade, N; Velikova, T; Hasan, Atmt; Shumnalieva, R; Milchert, M; Tan, CL; Edgar Gracia-Ramos, A; Cavagna, L; Vaidya, B; Kuwana, M; Sazliyana Shaharir, S; Knitza, J; Makol, A; Zamora Tehozol, EA; Rojas Serrano, J; Halabi, H; Dey, D; Toro Gutierrez, CE; Akawatcharangura Goo, P; Caballero Uribe, CV; Distler, O; Katchamart, W; Day, J; Parodis, I; Nikiphorou, E; Chinoy, H; Agarwal, V; Gupta, L;
- Journal Title
- Rheumatology
- Publication Type
- Sep 25 epub ahead of print
- Abstract
- OBJECTIVE: The presence of comorbidities can substantially affect patients' quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. METHODS: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs), and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined Basic Multimorbidity (BM) as the presence of ≥ 2 non-rheumatic chronic conditions and Complex Multimorbidity (CM) as the presence of ≥ 3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical Clustering on Principal Components was performed for grouping. RESULTS: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs, and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (OR: 1.62 vs oAIRDs and 2.95 vs HCs, p< 0.01), BM (OR 1.66 vs oAIRDs and 3.52 vs HCs, p< 0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, p< 0.01), and mental health disorders (MHDs) (OR 1.33 vs oAIRDs and 2.63 vs HCs, p< 0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all p< 0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM, and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. CONCLUSION: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.
- Publisher
- Oxford Academic
- Keywords
- Observational studies; autoinflammatory condition; comorbidity; myositis; quality of life
- Research Division(s)
- Inflammation
- PubMed ID
- 39324556
- Publisher's Version
- https://doi.org/10.1093/rheumatology/keae520
- Open Access at Publisher's Site
https://doi.org/10.1093/rheumatology/keae520- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-10-04 10:44:56
Last Modified: 2024-10-04 10:51:24