The dynamics of the metastatic niche: Lung alveolar type 2 cell reprogramming and cancer cell stemness
- Author(s)
- Leiwe, M; Asselin-Labat, ML;
- Details
- Publication Year 2024-09-23,Volume 59,Issue #18,Page 2393-2395
- Journal Title
- Developmental Cell
- Abstract
- The complex cellular interactions supporting metastasis formation remain incompletely understood. In this issue of Developmental Cell, Rodrigues et al. describe a positive feedback loop within the lung metastatic niche, whereby disseminated cancer cells promote the multilineage potential of alveolar type 2 cells, favoring cancer cell stemness and metastasis initiation.
- Publisher
- Cell Press
- Keywords
- Humans; *Cellular Reprogramming; *Lung Neoplasms/pathology/secondary; *Neoplastic Stem Cells/pathology/metabolism; *Neoplasm Metastasis/pathology; Alveolar Epithelial Cells/metabolism/pathology; Animals; Tumor Microenvironment; Stem Cell Niche
- Research Division(s)
- Personalised Oncology
- PubMed ID
- 39317163
- Publisher's Version
- https://doi.org/10.1016/j.devcel.2024.07.014
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-10-04 10:45:03
Last Modified: 2024-10-04 10:51:24