Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia
- Author(s)
- Brown, FC; Wang, X; Birkinshaw, RW; Chua, CC; Morley, TD; Kasapgil, S; Pomilio, G; Blombery, P; Huang, DCSProfessor; Czabotar, PE; Priore, SF; Yang, G; Carroll, MP; Wei, AH; Perl, AE;
- Journal Title
- Blood Advances
- Publication Type
- Oct 7 epub ahead of print
- Abstract
- We report and characterize three venetoclax-resistant BCL2 variants arising during venetoclax/azacitidine therapy in acute myeloid leukemia (AML). Our results indicate the potential for on-target venetoclax resistance in patients with AML at relapse.
- Publisher
- ASH
- Research Division(s)
- Blood Cells And Blood Cancer; Structural Biology
- PubMed ID
- 39374584
- Publisher's Version
- https://doi.org/10.1182/bloodadvances.2024014446
- Open Access at Publisher's Site
https://doi.org/10.1182/bloodadvances.2024014446- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-10-09 01:19:10
Last Modified: 2024-10-09 01:19:21