Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia
- Author(s)
- Brown, FC; Birkinshaw, R; Wang, X; Morley, T; Huang, DCS; Chua, CC; Czabotar, P; Carroll, M; Kasapgil, S; Pomilio, G; Blombery, P; Priore, SF; Yang, G; Wei, AH; Perl, AE;
- Details
- Publication Year 2025-01-14,Volume 9,Issue #1,Page 127-131
- Journal Title
- Blood Advances
- Abstract
- We report and characterize three venetoclax-resistant BCL2 variants arising during venetoclax/azacitidine therapy in acute myeloid leukemia (AML). Our results indicate the potential for on-target venetoclax resistance in patients with AML at relapse.
- Publisher
- ASH
- Research Division(s)
- Blood Cells And Blood Cancer; Structural Biology; Blood Cells and Blood Cancer
- PubMed ID
- 39374584
- Publisher's Version
- https://doi.org/10.1182/bloodadvances.2024014446
- Open Access at Publisher's Site
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Creation Date: 2024-10-09 01:19:10
Last Modified: 2026-03-16 03:26:25