Don't fear the reaper: The role of regulated cell death in tumorigenesis and BH3-mimetics for cancer therapy
- Author(s)
- La Marca, JE; Kelly, GL; Strasser, A; Diepstraten, ST;
- Details
- Publication Year 2024-10-07,Volume 59,Issue #19,Page 2532-2548
- Journal Title
- Developmental Cell
- Abstract
- From its earliest characterization, it has been recognized that there is a role for regulated (programmed) cell death in cancer. As our understanding of the different types of programmed cell death processes and their molecular control has advanced, so have the technologies that allow us to manipulate these processes to, for example, fight against cancer. In this review, we describe the roles of the different forms of regulated cell death in the development of cancer as well as their potential therapeutic exploitation. In that vein, we explore the development and use of BH3-mimetics, a unique class of drugs that can directly activate the apoptotic cell death machinery to treat cancer. Finally, we address key challenges that face the field to improve the use of these therapeutics and the efforts that are being undertaken to do so.
- Publisher
- Cell Press
- Keywords
- Humans; *Neoplasms/drug therapy/pathology; *Carcinogenesis/pathology; *Apoptosis/drug effects; Animals; Regulated Cell Death
- Research Division(s)
- Blood Cells And Blood Cancer
- PubMed ID
- 39378839
- Publisher's Version
- https://doi.org/10.1016/j.devcel.2024.06.018
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-10-25 10:15:30
Last Modified: 2024-10-25 10:15:53