Soluble CD52 mediates immune suppression by human seminal fluid
- Author(s)
- Harrison, LC; Stone, NL; Bandala-Sanchez, E; Huntington, ND; McLachlan, RI; Rautela, J; O'Bryan, MK;
- Journal Title
- Frontiers in Immunology
- Abstract
- Seminal fluid provides for the carriage and nutrition of sperm, but also modulates immunity to prevent allo-rejection of sperm by the female. Immune suppression by seminal fluid has been associated with extracellular vesicles, originally termed prostasomes, which contain CD52, a glycosylated glycophosphoinositol-anchored peptide released from testicular epithelial cells. Previously, we reported that human T cell-derived CD52, bound to the danger-associated molecular pattern protein, high mobility group box 1 (HMGB1), suppresses T cell function via the inhibitory sialic acid-binding immunoglobulin-like lectin-10 (Siglec-10) receptor. Here we show that human seminal fluid contains high concentrations of CD52 complexed with HMGB1, which mediates T cell suppression indirectly via Siglec-7 on antigen-presenting cells. Proliferation of natural killer (NK) cells, which express Siglec-7 and play a key role in the immune defence of the uterus, was directly suppressed by seminal fluid CD52. These findings elucidate a critical function of seminal fluid to suppress cellular immunity and facilitate reproduction.
- Publisher
- Frontiers
- Keywords
- Humans; *Semen/immunology/metabolism; *CD52 Antigen/metabolism/immunology; Male; *Killer Cells, Natural/immunology/metabolism; T-Lymphocytes/immunology/metabolism; Antigens, Differentiation, Myelomonocytic/metabolism/immunology; Lectins/metabolism/immunology; Female; Immune Tolerance; HMGB1 Protein; Cd52; Hmgb1; NK cell; Siglec-7; T cell; seminal fluid
- Research Division(s)
- Immunology
- PubMed ID
- 39737172
- Publisher's Version
- https://doi.org/10.3389/fimmu.2024.1497889
- Open Access at Publisher's Site
https://doi.org/10.3389/fimmu.2024.1497889
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-20 03:39:07
Last Modified: 2025-01-21 10:53:44