Soluble CD52 mediates immune suppression by human seminal fluid
Journal Title
Frontiers in Immunology
Abstract
Seminal fluid provides for the carriage and nutrition of sperm, but also modulates immunity to prevent allo-rejection of sperm by the female. Immune suppression by seminal fluid has been associated with extracellular vesicles, originally termed prostasomes, which contain CD52, a glycosylated glycophosphoinositol-anchored peptide released from testicular epithelial cells. Previously, we reported that human T cell-derived CD52, bound to the danger-associated molecular pattern protein, high mobility group box 1 (HMGB1), suppresses T cell function via the inhibitory sialic acid-binding immunoglobulin-like lectin-10 (Siglec-10) receptor. Here we show that human seminal fluid contains high concentrations of CD52 complexed with HMGB1, which mediates T cell suppression indirectly via Siglec-7 on antigen-presenting cells. Proliferation of natural killer (NK) cells, which express Siglec-7 and play a key role in the immune defence of the uterus, was directly suppressed by seminal fluid CD52. These findings elucidate a critical function of seminal fluid to suppress cellular immunity and facilitate reproduction.
Publisher
Frontiers
Keywords
Humans; *Semen/immunology/metabolism; *CD52 Antigen/metabolism/immunology; Male; *Killer Cells, Natural/immunology/metabolism; T-Lymphocytes/immunology/metabolism; Antigens, Differentiation, Myelomonocytic/metabolism/immunology; Lectins/metabolism/immunology; Female; Immune Tolerance; HMGB1 Protein; Cd52; Hmgb1; NK cell; Siglec-7; T cell; seminal fluid
Research Division(s)
Immunology
PubMed ID
39737172
Open Access at Publisher's Site
https://doi.org/10.3389/fimmu.2024.1497889
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2025-01-20 03:39:07
Last Modified: 2025-01-21 10:53:44
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