ILC1 as critical gatekeepers in autoimmune kidney damage
- Author(s)
- Seillet, C; Xiong, L;
- Details
- Publication Year 2025-01,Volume 103,Issue #1,Page 9-11
- Journal Title
- Immunology and Cell Biology
- Abstract
- A recent article has shown that blocking NKp46 signaling reduces injury, highlighting these cells as key drivers of organ damage and potential therapeutic targets in autoimmune diseases. In lupus nephritis, NKp46(+) ILC1s orchestrate kidney inflammation by producing CSF2, driving the expansion of pro-inflammatory macrophages that infiltrate epithelial niches and exacerbate tissue damage.
- Publisher
- Wiley
- Keywords
- Humans; Animals; *Lupus Nephritis/immunology/pathology; Kidney/pathology/immunology; Autoimmune Diseases/immunology/pathology; Macrophages/immunology/metabolism; Natural Cytotoxicity Triggering Receptor 1/metabolism; Signal Transduction; inflammation; innate lymphoid cells; systemic lupus erythematosus (SLE)
- Research Division(s)
- Immunology
- PubMed ID
- 39642908
- Publisher's Version
- https://doi.org/10.1111/imcb.12842
- Open Access at Publisher's Site
https://doi.org/10.1111/imcb.12842- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-21 11:04:34
Last Modified: 2025-01-21 11:06:43