Reacting to reductive stress at the mitochondrial import gate
- Author(s)
- Callegari, S;
- Journal Title
- Trends in Cell Biology
- Publication Type
- Jan 13 epub
- Abstract
- A byproduct of mitochondrial energy production is the generation of reactive oxygen species (ROS). Too much ROS is toxic, but ROS deficiency is equally deleterious (reductive stress). In a recent study, McMinimy et al. uncovered a ubiquitin proteasome-mediated mechanism at the translocase of the outer membrane (TOM) complex, which senses ROS depletion and adjusts mitochondrial protein import accordingly.
- Publisher
- Cell Press
- Keywords
- TOM complex; mitochondrial import; proteasome; reactive oxygen species; reductive stress; ubiquitin
- Research Division(s)
- Ubiquitin Signalling
- PubMed ID
- 39809643/
- Publisher's Version
- https://doi.org/10.1016/j.tcb.2024.12.013
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-02-07 11:22:04
Last Modified: 2025-02-07 11:24:04