Rationale and Ethical Assessment of an Oropharyngeal Gonorrhoea Controlled Human Infection Model
- Author(s)
- Williams, E; Hocking, JS; Fairley, CK; Chen, MY; Williamson, DA; McCarthy, JS; Jamrozik, E;
- Journal Title
- Journal of Infectious Diseass
- Publication Type
- Jan 18 epub
- Abstract
- Infection with Neisseria gonorrhoeae, the causative agent of gonorrhoea, causes significant morbidity worldwide and can have long-term impacts on reproductive health. The greatest global burden of gonorrhoea occurs in low- and middle-income settings. Global public health significance is increasing due to rising antimicrobial resistance (AMR), which threatens future gonorrhoea management. The oropharynx is an important asymptomatic reservoir for gonorrhoea transmission and a high-risk site for development of AMR and treatment failure. Controlled human infection model (CHIM) studies using N. gonorrhoeae may provide a means to accelerate the development of urgently needed therapeutics, vaccines and other biomedical prevention strategies. A gonorrhoea urethritis CHIM has been used since the 1980s with no reported serious adverse events. Here, we describe the rationale for an oropharyngeal gonorrhoea CHIM, including analysis of potential ethical issues that should inform the development of this novel study design.
- Publisher
- Oxford Academic
- Keywords
- Controlled human infection model; ethics; gonorrhoea; sexually transmitted infection
- Research Division(s)
- Infection and Global Health
- PubMed ID
- 39825788
- Publisher's Version
- https://doi.org/10.1093/infdis/jiaf029
- Open Access at Publisher's Site
https://doi.org/ 10.1093/infdis/jiaf029- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-02-07 11:22:13
Last Modified: 2025-02-07 11:24:04